The Shiwarski Tissue Engineering Lab develops human-relevant 3D bioprinted tissue and vascular models to study mechanobiology, disease progression, and therapeutic response. Our research integrates biofabrication, biomaterials engineering, and open-source hardware to create perfusable, mechanically tunable systems that replicate native tissue geometry and function. These platforms enable mechanistic investigation of cardiovascular disease, pulmonary hypertension, thrombosis, and precision diagnostics by bridging fundamental biology with translational bioengineering.

On this site, you can explore peer-reviewed research from the Shiwarski Tissue Engineering Lab advancing 3D bioprinting, vascular tissue engineering, mechanotransduction, and human-relevant disease models. This publications collection highlights innovations in perfusable biomaterials, biofabrication hardware, organ-specific microphysiological systems, and open-source bioprinting technologies. 

Examples of work include:

• translational tissue engineering publications, perfusable vascular disease models, mechanobiology and mechanotransduction research, biomaterials for cardiovascular disease modeling, human-relevant 3D tissue models, open-source bioprinting research, microphysiological systems for disease modeling, pulmonary hypertension tissue models