Development of a Collagen-based 3D Bioprinted Microfluidic Platform for Vascular Tissue Engineering and Disease Modeling

• This proposal will use FRESH 3D bioprinting and a newly developed biomechanical strain sensor to 3D bioprint a functional resistance artery and create an ECM- based vascular microfluidic platform to improve our understanding of hypertensive disease progression.

Development of a Collagen-based 3D Bioprinted Microfluidic Platform for Vascular Tissue Engineering and Disease Modeling

• This proposal will use FRESH 3D bioprinting and a newly developed biomechanical strain sensor to 3D bioprint a functional resistance artery and create an ECM- based vascular microfluidic platform to improve our understanding of hypertensive disease progression.

Development of a Full-biologic 3D bioprinted Hepatic Sinusoid Model for Improved Risk Stratification of Thrombosis Burden in Fontan-treated Single-ventricle Patients

• This proposal aims to characterize the coagulation activity of Fontan recipients using a novel 3D bioprinted collagen-based microfluidics system. Initial results will focus on validating the model design, fabrication, and confirming the capability for a fully 3D bioprinted CHIPS to detect thrombosis via platelet aggregation and activation.