A New Phase for WNK Kinase Signaling Complexes as Biomolecular Condensates
Boyd-Shiwarski CR, Shiwarski DJ, Subramanya AR. Physiology (2024)
WNK Kinases sense molecular crowding and rescue cell volume via phase separation
Boyd-Shiwarski CR*, Shiwarski DJ*, Griffiths SE, Beacham RT, Norrell L, Morrison DE, Wang J, Mann J, Tennant W, Anderson EN, Franks J, Calderon M, Connolly KA, Weaver CJ, Weckerly CC, Pandey UB, Donnelly CJ, Sun D, Rodan AR, Subramanya AR. Cell (2022) *Equal Contributions
Endothelial superoxide dismutase 2 is decreased in sickle cell disease and regulates fibronectin processing
Dosunmu-Ogunbi A, Yuan S, Shiwarski DJ, Tashman JW, Reynolds M, Feinberg AW, Novelli EM, Shiva S, Straub AC. Function (2022)
Effects of extreme potassium stress on blood pressure and renal tubular sodium transport
Boyd-Shiwarski CR, Weaver C, Beacham R, Shiwarski DJ, Connolly K, Nkashama L, Mutchler S, Griffiths S, Knoell S, Marciszyn A, Subramanya AR. AJP Renal (2020) PMID: 32281415
Dual RXR motifs regulate NGF-mediated intracellular retention of the delta opioid receptor
Shiwarski DJ, Crilly SE, Dates A, Puthenveedu MA. Mol Biol Cell. 2019 Jan 2:mbcE18050292. doi: 10.1091/mbc.E18-05-0292. PubMed PMID: 30601694.
Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent
Boyd-Shiwarski CR, Shiwarski DJ, Roy A, Namboodiri HN, Nkashama LJ, Xie J, McClain KL, Marciszyn A, Kleyman TR, Tan RJ, Stolz DB, Puthenveedu MA, Huang CL, Subramanya AR. Mol Biol Cell. 2018 Feb 15;29(4):499-509. PMID: 29237822; PubMed Central PMCID: PMC6014176.
TMEM16A/ANO1 Inhibits Apoptosis Via Downregulation of Bim Expression
Godse NR, Khan N, Yochum ZA, Gomez-Casal R, Kemp C, Shiwarski DJ, Seethala RS, Kulich S, Seshadri M, Burns TF, Duvvuri U. Clin Cancer Res. 2017 Dec 1;23(23):7324-7332. doi: 10.1158/1078-0432.CCR-17-1561. 2017 Sep 12. PMID: 28899969; PMCID: PMC5898434.
PI3K Class II α regulates δ-Opioid Receptor Export from the trans-Golgi Network
Shiwarski DJ, Darr M, Telmer CA, Bruchez MP, Puthenveedu MA. PI3K Class II α regulates δ-Opioid Receptor Export from the trans-Golgi Network. Mol. Biol. Cell. 2017 May 31;mbc.E17–01–0030. PMID: 28566554
A PTEN-Regulated Checkpoint Controls Surface Delivery of δ Opioid Receptors.
Shiwarski DJ, Tipton A, Giraldo MD, Schmidt BF, Gold MS, Pradhan AA, Puthenveedu MA. J. Neurosci. 2017 Apr 5;37(14):3741–52. PMID: 28264976
Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor
Weinberg ZY, Zajac AS, Phan T, Shiwarski DJ, Puthenveedu MA. Molecular Pharmacology. 2017 Apr;91(4):416–27. PMID: 28153854
Shiwarski Tissue Engineering Lab
University of Pittsburgh
Bioengineering and Medicine
Vascular Medicine Institute
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